Antibiotic Resistance Evidence of “Devolution”

Updated near the bottom.

The issue involved in the above video is not evolution, but in fact, DEVOLUTION. In other words, “no newly evolved complex information has been demonstrated,” EVOLUTION NEWS AND VIEWS continues with a quote and then some commentarry [I am working on getting the graphic mentioned]:

A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying environmental challenges. Laboratory experiments, however, often study evolution in well-mixed systems. Here, we introduce an experimental device, the microbial evolution and growth arena (MEGA)-plate, in which bacteria spread and evolved on a large antibiotic landscape (120 × 60 centimeters) that allowed visual observation of mutation and selection in a migrating bacterial front. While resistance increased consistently, multiple coexisting lineages diversified both phenotypically and genotypically. Analyzing mutants at and behind the propagating front, we found that evolution is not always led by the most resistant mutants; highly resistant mutants may be trapped behind more sensitive lineages. The MEGA-plate provides a versatile platform for studying microbial adaption and directly visualizing evolutionary dynamics.

The key to understanding the paper is its Figure 3C. There it shows the genes that have undergone more than one mutation across tested bacteria. They break the mutations down into silent changes, changes of amino acids (point mutations), and insertion-deletion or nonsense mutations, which almost certainly are loss of function (LOF). Over half of genes contain such LOF mutations, along with some point mutations, which likely also degrade or destroy function. In other words, devolution….

In another post over at EVOLUTION NEWS AND VIEWS, it is mentioned that “Evolutionists often speak in generalities about beneficial mutations. They may be rare, we are assured, but they happen.” But is this the case? Continuing we read:

…when they do [happen], “natural selection is daily and hourly scrutinising, throughout the world, every variation, even the slightest; rejecting that which is bad, preserving and adding up all that is good; silently and insensibly working, whenever and wherever opportunity offers, at the improvement of each organic being in relation to its organic and inorganic conditions of life” (Darwin, Origin of Species). All right, we have some data to look at. We can put a number to the frequency of beneficial mutations in a large sample. The number is zero.

Genome sequencing technology has progressed very rapidly in only the last few years. NATURE just published results of the Exome Aggregation Consortium (ExAC), the largest survey of human genes to date. (An “exome” is the portion of the genome that codes for proteins.) The exomes from 60,706 individuals from a variety of ethnic groups have been collected and analyzed. If we multiply 60,000 people by the 20,000 genes in the human genome (the lowest estimate), we get a minimum of 1.2 billion genes that have been examined by ExAC for variants. That sounds like a pretty good sample size for scrutinizing some of those beneficial variations that Darwin said his law of natural selection could add up and preserve.

Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNAsequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC). This catalogue of human genetic diversity contains an average of one variant every eight bases of the exome, and provides direct evidence for the presence of widespread mutational recurrence. We have used this catalogue to calculate objective metrics of pathogenicity for sequence variants, and to identify genes subject to strong selection against various classes of mutation; identifying 3,230 genes with near-complete depletion of predicted protein-truncating variants, with 72% of these genes having no currently established human disease phenotype. Finally, we demonstrate that these data can be used for the efficient filtering of candidate disease-causing variants, and for the discovery of human ‘knockout’ variants in protein-coding genes. [Emphasis added.]

Out of this high ratio of variants (one in eight bases shows variation, they said), there should be some proportion, even if small, that improves fitness. But we search the paper in vain for any mention of beneficial mutations. There’s plenty of talk about disease. The authors only mention “neutral” variants twice. But there are no mentions of beneficial mutations. You can’t find one instance of any of these words: benefit, beneficial, fitness, advantage (in terms of mutation),improvement, innovation, invention, or positive selection.

They mention all kinds of harmful effects from most variants: missense and nonsense variants, frameshift mutations, proteins that get truncated on translation, and a multitude of insertions and deletions. Quite a few are known to cause diseases. There are probably many more mutations that never survive to birth. As for natural selection, the authors do speak of “negative selection” and “purifying selection” weeding out the harmful mutations, but nowhere do they mention anything worthwhile that positive selection appears to be preserving…

Yep. I note this “devolution” in a conversation with a biology graduate student in regards to evidences for the GENERAL THEORY OF EVOLUTION (GTE).

▼ It has been proven that resistance to many modern antibiotics was present decades before their [the antibiotics] discovery. In 1845, sailors on an ill-fated Arctic expedition were buried in the permafrost and remained deeply frozen until their bodies were exhumed in 1986. Preservation was so complete that six strains of nineteenth-century bacteria found dormant in the contents of the sailors’ intestines were able to be revived! When tested, these bacteria were found to possess resistance to several modern-day antibiotics, including penicillin. Such traits were obviously present prior to penicillin’s discovery, and thus could not be an evolutionary development. (Medical Tribune, December 29, 1988, p. 1, 23.)

In 1998, the National Academy of Sciences published and distributed a book to public schools and other institutions entitled Teaching About Evolution and the Nature of Science. Jonathan Sarfati, Ph.D., F.M., wrote a book, Refuting Evolution, which is a topic by topic rebuttal to this Academy of Sciences publication. Under the evidence for evolution in the evolutionist text is the following quote:

▼ Similar episodes of rapid evolution are occurring in many different organisms. Rats have developed resistance to the poison warfain. Many hundreds of insect species and other agricultural pests have evolved resistance to the pesticides used to combat them – even to chemical defenses genetically engineered into plants.

(Sarfati’s reply – any words in the [boxes] are mine):

▼ However, what has this to do with the evolution of new kinds with new genetic information? Precisely nothing. What has happened in many cases is that some bacteria already had the genes for resistance to the antibiotics. In fact, some bacteria obtained by thawing sources which had been frozen before man developed antibiotics have shown to be antibiotic-resistant [6 different antibiotics in fact, penicillin in modern doses – which is way beyond the strength of natural penicillin found in nature]. When antibiotics are applied to a population of bacteria, those lacking resistance are killed, and any genetic information they carry is eliminated. The survivors carry less information [or specificity], but they are all resistant. The same principle applies to rats and insects “evolving” resistance to pesticides. Again, the resistance was already there, and creatures without resistance are eliminated.

[Much like if we killed all dogs (including Canis Domesticus and Canis Lupus) except for Chihuahuas, we would permanently lose the information of the parent population. You could then breed Chihuahuas for a millennium and not get an Irish Wolfhound]

▼ …In other cases, antibiotic resistance is the result of a mutation, but in all known cases, this mutation has destroyed information. It may seem surprising that destruction of information can sometimes help. But one example is resistance to the antibiotic penicillin. Bacteria normally produce an enzyme, penicillinase, which destroys penicillin. The amount of penicillinase is controlled by a gene. There is normally enough produced to handle any penicillin encountered in the wild, but the bacterium is overwhelmed by the amount given to patients. A mutation disabling this controlling gene results in much more penicillinase being produced.

[Thus, the bacteria found frozen in 1845 already had the mutation to overcome modern medical doses of penicillin. So the mutation wasn’t the result of the penicillin in modern doses, thus seemingly becoming resistant… it already had the resistant mutation – informational or specificity losing – in the population. In other words, no new information was added to the parent population!]

(See more in this entire chapter discussing the issue: “VARIATION AND NATURAL SELECTION VERSUS EVOLUTION“)

Updated info with a h-t to ‎TOMI AALTO’S site‎ and it comes by way of PHYS.ORG:

Excerpt: “Pioneering work being carried out in a cave in New Mexico by researchers at McMaster University and The University of Akron, Ohio, is changing the understanding of how antibiotic resistance may have emerged and how doctors can combat it in the future.

In research published in Nature Communications today, the scientists examined one bacterium found 1,000 feet underground (called Paenibacillus) that demonstrated resistance to most antibiotics used today, including so-called ‘drugs of last resort’ such as daptomycin. These microorganisms have been isolated from the outside world for more than four million years within the cave.

The results show the bacterium is resistant to 18 different antibiotics and uses identical methods of defense as similar species found in soils.

Among the different ways that the bacteria could be resistant to antibiotics, the scientists identified five novel pathways that were of potential clinical concern. Finding these new pathways is particularly valuable, as it gives researchers time to develop new drugs to combat this type of resistance, potentially decades before it will become a problem for doctors and their patients.

“The diversity of antibiotic resistance and it’s its prevalence in microbes across the globe should be humbling to everyone who uses these lifesaving drugs,” said Gerry Wright, an author of the paper and scientific director of McMaster’s Michael G. DeGroote Institute for Infectious Disease Research.

“It reflects the fact that we must understand that antibiotic use and resistance go hand in hand.”

My [Tomi’s] comment: How could anyone talk about bacterium evolution after this finding? We can’t observe evolution, we can only observe reaction and adaptation. We can also see strong evolutionary stasis here. Bacteria have not experienced changes in assumed millions of years. They have not evolved the ability to rapidly adapt to modern medicines. Instead, they already have all necessary genomic information and capabilities for ecological adaptation. These features are built in by Intelligent source and the Creator. The evolutionary theory is a dangerous heresy.

Not Enough Evolutionary Time For Simple Life


OTHER EVIDENCES TO CONSIDER

Not Enough Time


It’s even in the title of Charles Darwin’s most popular book, On the Origin of Species By Means of Natural Selection. But what Darwin didn’t know then was that natural selection can’t create brand-new genetic information. It’s never been observed to do this. In the case of the bacterium we looked at, it either LOST information or gained already existing information. Nothing brand-new was created! So, if natural selection can never create the brand-new information that evolution needs, how can it be considered the driving force of evolution? Just one more scientific reason that you shouldn’t believe in molecules-to-man evolution. It takes a LOT of faith.

Proof that God (a non-random process) exists and random chance evolutionary processes do not explain our origins.

Stephen C. Meyer appearing in Darwin’s Dilemma talks about Richard Dawkins’s “climbing Mt. Improbable.”

Biologist Ann Gauger discusses the challenge posed to Darwinian natural selection by the process of metamorphosis found in butterflies and other creatures. Gauger is featured in the science documentary “Metamorphosis,” which deals with butterflies, evolution, and intelligent design.

RNA/DNA = Information | Or, What “IS” Information

✦ “My whole life has been guided by the principle of Plato’s Socrates: Follow the evidence, wherever it leads.” After chewing on his scientific worldview for more than five decades, Flew concluded, “A super-intelligence is the only good explanation for the origin of life and the complexity of nature.” Previously, in his central work, The Presumption of Atheism (1976), Flew argued that the “onus of proof [of God] must lie upon the theist.” However, at the age of 81, Flew shocked the world when he renounced his atheism because “the argument for Intelligent Design is enormously stronger than it was when I first met it.” | Antony Flew |

What naturalism is is described in the last paragraph. It is also described in a more relational way here, “Love.”

Professor Werner Gitt – Director and professor at the German Federal Institute of Physics and Technology – tells us that:

“The highest information density known to us is that of DNA molecules…. The storage capacity of DNA, the information carriers of living things, is 4.5 x 10 (to the 13th power) times more effective than a megachip!… The sum total of knowledge currently stored in the libraries of the world is estimated at 10(to the 18th power) bits. If this information could be stored in DNA molecules, 1% of the volume of a pinhead would be sufficient for this purpose. If, on the other hand, this information were to be stored with aid of megachips, we would need a pile higher than the distance between the earth and the moon.”

The DNA molecule, of which even the simplest – some would say the most “primitive” – forms of life are composed, is thus 45 million million times more efficient at holding and conveying information than a megachip. This is because the DNA molecule is an incredibly complex three-dimensional information storage system, where the megachip is only two-dimensional. But the DNA molecules ability to store and convey such inconceivably large amounts of information so efficiently does not tell us where the itself comes from. What is the source of that?

Information Theory, of which Professor Gitt is one of the world’s leading exponents, is an important branch of scientific investigation which has shown conclusively and consistently that information cannot and does not arise from any state of non-information, just as life cannot proceed from non-life. Moreover, information has now come to be recognized as the Third Fundamental Quantity of the universe, which hitherto was thought to consist of merely two fundamental quantities, those of matter and energy. The DNA molecule is, of course, matter. Its activities are funded by energy. But the information that it carries is something else entirely. In other words, it is not sufficient to have only matter and energy for DNA to work. What is also required, at least to begin with, is a massive input of information for which matter and energy can give no account, and which neither of them can supply. Again, Professor Gitt:

“According to Norbert Wiener, the founder of cybernetics and information theory, information cannot be of a physical nature, even though it is transmitted by physical means: ‘Information in information, neither matter nor energy. No materialism that fails to take account of this can survive the present day.’”

Because of the increasing disillusionment with the role of chance, a shift took place in the late 60’s and the 70’s to the view that life was somehow the inevitable outcome of nature’s laws at work over vast spans of time. Terms such as “directed chance” and “biochemical predestination” have entered the scientific literature to mean that life was somehow the result of the inherent properties of matter.

But more discomforting still to the materialist, is not just the recent discovery of information to be the Third Fundamental Quantity, but rather the startling realization of its source:

“If a basic code is found in any system, it can be concluded that the system originated from a mental concept, and did not arise by chance…. Meanings always represent mental concepts. They are distinct from matter and energy. They originate from an intelligent source. It is by means of language that information may be stored and transmitted on physical carriers. The information itself is invariant…. The reason for this invariance lies in its non-material nature.”

DNA stores literally coded information || DNA contains codified information || The various codes in the cell

It would seem then that while some materialists have been busy looking in all the wrong places, certain physicists have stumbled upon the Mind of God.

The problem with most of modern science is that the philosophy of reductionism is the ruling paradigm. According to George Williams, a scientist of some stature in the evolutionary community, the crucial object of selection in evolution is inherently non-material:

“Evolutionary biologists have failed to realize that they work with two more or less incommensurable domains: that of information and that of matter…. These two domains can never be brought together in any kind of the sense usually implied by the term ‘reductionism.’ … The gene is a package of information, not an object. The pattern of base pairs in a DNA molecule specifies the gene. But the DNA molecule is the medium, its not the message…. Just the fact that fifteen years ago I started using a computer may have had something to do with my ideas here. The constant process of transferring information from one physical medium to another and then being able to recover the same information in the original medium brings home the separability of information and matter. In biology, when you’re talking about things like genes and genotypes and gene pools, you’re talking about information, not physical objective reality.”

Perhaps evolutionary biologists have avoided noticing that information and matter are fundamentally different things because that insight is fatal to the whole reductionist project in biology. If the message is truly not reducible to the medium, then trying to explain the creation of the information by a materialistic theory is simply a category mistake. One might as well try to explain the origin of a literary work [say, Hamlet] by invoking the chemical laws that govern the combining of ink and paper, and then proposing speculative hypotheses about how those laws (with boost from chance but without intelligence) might have generated meaningful sentences.

Here is some more wonderful information I updated in another post that came from a conversation at Starbucks:


Preliminary Hearing at Starbucks


I had a wonderful conversation with a very nice fellow at Starbucks (I will simply refer to him at times as John D.). The encounter started because of the book I was reading and an unsolicited question about it. It was only AFTER the conversation that I noted why question about the book was asked. The book was “Undeniable: How Biology Confirms Our Intuition That Life Is Designed.” (Watch the author speak about the book HERE.) After the conversation had concluded, I realized what drew John D. into engaging me. During the conversation, as you will see, he intimated that he was a lawyer. Hence, the large title that drew him in is “Undeniable.”

Light conversation took place about the book, mainly because I am just beginning the book and do not know the content well enough yet to discuss it specifically. I did steer the conversation towards DNA just a tad — with Stephen Meyer’s book in mind.

For the reader of this post, keep in mind that while I did not go in-depth into the discussion of DNA that immediately follows, I did reference briefly the aspects of information being separate from the means of transmission [matter]:

Evolutionary biologist George Williams observed: “Evolutionary biologists have failed to realize that they work with two more or less incommensurable domains: that of information and that of matter…. The gene is a package of information, not an object. The pattern of base pairs in a DNA molecule specifies the gene. But the DNA molecule is the medium, it’s not the message…. These two domains will never be brought together in any kind of the sense usually implied by the term ‘reductionism. Information doesn’t have mass or charge or length in millimeters. Likewise, matter doesn’t have bytes…. This dearth of shared descriptors makes matter and information two separate domains of existence, which have to be discussed separately, in their own terms.”[1]

As the information theorist Hubert Yockey observes, the “genetic code is constructed to confront and solve the problems of communication and recording by the same principles found . . . in modern communication and computer codes.” Yockey notes that “the technology of information theory and coding theory has been in place in biology for at least 3.85 billion years,” or from the time that life first originated on earth. What should we make of this fact? How did the information in life first arise?[2]

Codes are not matter and they’re not energy. Codes don’t come from matter, nor do they come from energy. Codes are information, and information is in a category by itself.[3]information

A great example is a newspaper.[4] If you read an article on a topic that is information being passed on to you by another intelligence. The modern roadblock for today’s naturalist is the problem of looking at the molecules that make up the ink printed page stores information via the 26 letters of the alphabet as somehow related to the origin of the information being passed on. The problem is that the newspaper is merely the medium, for the information. Like a Compact Disc is for music. The CD is merely the medium to carry the information.

The next question is, how much information can the DNA molecule hold?

a) A pinhead made of DNA: Let us imagine we had enough DNA to fill the volume of a pinhead with a diameter of 2 mm. How many paperbacks (each with 189 pages as in [G19]) could be represented by the information held in that amount of DNA? Answer: about 25 trillion. That would be a pile of these paperback books approximately 920 times the distance from the earth to the moon (384,000 km). In 2011, if we were to equally distribute these paperbacks amongst the approximately 6.93 billion people on Earth, every person would receive about 3,600 copies.

b) Drawing a wire: Now let us stretch the material of the 2 mm diameter pinhead into a wire of the same thickness as the DNA molecule (2 x 10-6 mm). How long would this wire be? Unbelievably, it would stretch 33 times around the equator, which has a circumference of 24,860 miles (40,000 km).

c) One thousandth of a gram of DNA: If we were to take a milligram (1 mg = 10-3 g) of a (double helix) strand of DNA material, it would almost stretch from the earth to the moon![5]

(Click to enlarge)

Dr. George Church, a pioneering molecular geneticist at Harvard/MIT, informed us in a Sciencexpress article in August of 2012, that the digital-information storage capacity of DNA is “very dense.” How dense? One gram of DNA can store 455 exabytes of information. For those readers like myself whose eyes glaze over as soon as computer nerds start talking about bytes and RAM’s I will put it in simple layman’s terms. One gram of DNA – the weight of two Tylenol – can store the same amount of digitally encoded information as a hundred billion DVD’s. Yes, you read correctly, I said a hundred billion DVD’s. Every single piece of information that exists on the Earth today; from every single library, from every single data base, from every single computer, could be stored in one beaker of DNA. This is the same DNA/Genetic Information/Self-Replication System that exists in humans and in bacteria (which are the simplest living organisms that exist today and have ever been known to exist). In short, our DNA-based genetic code, the universal system for all life on our planet, is the most efficient and sophisticated digital information storage, retrieval, and translation system known to man.[6]

I will repeat a line from the above graphic description:

  • “This particularly ingenious storage method reaches the limit of physical possibility.”

Let me give you another example of the same sort of reasoning. Imagine that you have just finished reading a fabulous novel. Wanting to read another book like it, you exclaim to a friend, “Wow! That was quite a book. I wonder where I can get a bottle of that ink?” Of course not! You wouldn’t give the ink and paper credit for writing the book. You’d praise the author, and look for another book by the same writer. By some twist of logic, though, many who read the fabulous DNA script want to give credit to the “ink (DNA base code) and paper (proteins)” for composing the code. In a novel, the ink and paper are merely the means the author uses to express his or her thoughts. In the genetic code, the DNA bases and proteins are merely the means God uses to express His thoughts.[7]

Human DNA is like a computer program but far, far more advanced than any software ever created.[8]

Information is information, neither matter nor energy. No materialism that fails to take account of this can survive the present day. – Norbert Weiner, MIT Mathematician and Father of Cybernetics[9]


[1] This is a fuller quote adapted from two sources: Donald E. Johnson, Probability’s Nature and Nature’s Probability : A Call to Scientific Integrity (Charleston, SC: Booksurge Publishing, 2009), 44; Stephen C. Meyer, Signature in the Cell: DNA and the Evidence for Intelligent Design (New York, NY: Harper One, 2009), 17.

[2] Meyer, ibid.

[3] Perry Marshall, Evolution 2.0: Breaking the Deadlock Between Darwin and Design (Dallas, TX: Benbella Books, 2016), 187.

[4] The graphic to the right of the footnote is from, Werner Gitt, In the Beginning Was Information (Bielefeld, Germany: Christliche Literatur-Verbreitung, 1997), 86.

[5]  Werner Gitt, Without Excuse (Atlanta, GA: Creation Book Publishers, 2011), 288 (graph from p. 286).

  • BTW, Without Excuse is an updated edition of the book in footnote number four.

[6] Moshe Averick, Atheistic Science is Rapidly Sinking in the Quicksand, algemeiner.

[7] Gary Parker, 1.3 The Origin of Life: DNA and Protein, AiG.

[8] Bill Gates, The Road Ahead (New York, NY: Penguin Group, 1995), 188.

[9] Stan Lennard, So Easy a Caveman Could Do It?, RtB.


Here is a great presentation[s] and a QandA by Stephen Meyer discussing his Signature In The Cell:

ONE MUST INCLUDE THESE OTHER POSTS AS WELL!!!


NANOTECHNOLOGY

NOT ENOUGH TIME

ANTIBIOTIC RESISTANCE

NATURAL SELECTION D.O.A.

VITAMIN C PSEUDOGENE


Natural Selection ~ D.O.A.

Stephen C. Meyer appearing in Darwin’s Dilemma talks about Richard Dawkins’s “climbing Mt. Improbable.”

Biologist Ann Gauger discusses the challenge posed to Darwinian natural selection by the process of metamorphosis found in butterflies and other creatures. Gauger is featured in the science documentary “Metamorphosis,” which deals with butterflies, evolution, and intelligent design.

Why This Post? It is a post dealing with Natural Selection, something I haven’t dealt with specifically on my site, here. I did post on the topic at my Blogspot site, but have — through conversation — felt the need to import it to my .com. It is in it’s original sense, a response to conversations that took place in a forum, so you will see names out of the blue that at one time were in context. (I will be responding to challenges that I am not well read on the topic, and when I wrote this response originally, I have more than doubled my library… so be aware that this is a conversation from 2000 posted on my old site in 2007.) I will also update it a bit based on newer conversation and dissent. A good portion of the older post comes from the excellent book, Darwin’s Enigma (esp this chapter).Founders Dead

…Palaeoecologists like me are now bringing a new perspective to the problem. If macroevolution really is an extrapolation of natural selection and adaptation, we would expect to see environmental change driving evolutionary change. Major climatic events such as ice ages ought to leave their imprint on life as species adapt to the new conditions. Is that what actually happens?

[….]

“The link between environmental change and evolutionary change is weak – not what Darwinists might have predicted”

[….]

This view of life leads to certain consequences. Macroevolution is not the simple accumulation of microevolutionary changes but has its own processes and patterns. There can be no “laws” of evolution….

(New Scientist)

Another evolutionist that shows the vacuous nature of natural selection via many generations of fruit flies and the mutagenic selections imposed on it’s “fitness,” — the famous Theodosius Dobzhansky Drosophila (the fruit fly) experiments. This creation of mutations that in effect “increased stress” of “natural” selection on this species disproved Darwin’s baby showed that the predictions made were disproved by the experiments.

It is similar to the experiment subjecting a cactus to the same conditions that had resulted in it mutating. To their amazement, no matter how many times they performed the experiment, the cactus only changed into that one mutated form. The scientists in this experiment did not get a myriad of dysfunctional mutations before getting a functioning cactus. They didn’t even get several different functioning cacti. The only result was this one mutation, and there seemed to be nothing random about it. (PP. 13-15)

One of the cornerstone theories within evolutionary (neo-Darwinian) thinking has been “natural selection.” Natural selection, long thought to be the initiating force behind the many changes that would have needed to occur if evolutionary theory is correct, is now being abandoned or at least moved a few notches down in importance. There is a lot of information below, so take you time, watch the video posted and the other (Dean Kenyon) I linked to further down in the post. If you are a biology student, you may learn quite a bit more than the teacher would have liked you to, for, you see… the modern day biology teacher isn’t going to teach you that there are disagreements within the scientific community on these issues, he or she is merely there in that classroom to protect a dogma.

Take note that this dated response was part of a larger conversation, so you will see names (handles) of people that I respond to.

The Rhetoric of Charles Darwin~ via John Angus Campbell:

Rapier, the site you referenced is well received. The evidence from the pre-Cambrian shows that oxygen was indeed present, in large number. This fact did away with the Miller – Urey experiment and the others that followed, as they posited an oxygen free environment. However, the site you mentioned rests on two glaring problems. I will elucidate somewhat. The first being:

“No matter whether the atoms of carbon, nitrogen, oxygen, and others were there at Earth’s formation, or arrived later in alien bodies from space, they constituted the building blocks of life. These elements by intrinsic chemical nature formed organic compounds that were washed by rain into the seas…. The very nature of carbon chemical bonding to itself and other atoms predetermines the formation of organic compounds, and the subsequent catalyzing of more complex organic compounds.”

This concept of “carbon chemical bonding to itself and other atoms predetermines the formation of organic compounds” is commonly referred to as Biochemical Predestination. The term was coined by Dean H. Kenyon (and his co-author G. Steinman) who wrote a university level textbook on this subject. Kenyon is the [now emeritus] professor of biology at the University of San Francisco and was a staunch evolutionist when he wrote the book Biochemical Predestination (McGraw-Hill, 1969), which was the best-selling advanced level book on chemical evolution in the decade of the 1970’s.

Keep in mind that these two guys started this line of thought. One of Dean Kenyon’s students gave him a copy of a book written by Dr. A. E. Wilder-Smith (who holds three earned Ph.D.’s) entitled The Creation of Life: A Cybernetic Approach to Evolution. In this book by Dr. Wilder, Dean Kenyon’s book is critiqued. Instead of Kenyon saying – “Well, Dr. Wilder is just a creationist, who would listen to him?” – Dr. Kenyon read the book and tried to answer the arguments in it against his own book. When he couldn’t, he began to investigate where the evidence led to… outside of his previous presuppositions, which were based on naturalism (evolutionary thinking).

Now, Dr. Kenyon refutes with the latest evidence offered, this can be found in an excellent video entitled Unlocking the Mystery of Life. When you said, “Firstly, you need to do some researching on the history of our planet…”, I have. I will comment again that I have over 2,000 books in my home library [now over 5,000], and outside of politics, the creation/evolution controversy takes up most of the space. I have well over 100 books by evolutionary biologists, archaeologists, physicists, geologists, etc. Also, I have well over 200 books by creation biologists, archaeologists, physicists, geologists, etc. I wonder if you have gone to the sources themselves like I have… in other words, read some good books on the matter at hand. Just a challenge for you to be open-minded, that’s all. Kenyon, for instance, says:

“No experimental system yet devised has provided the slightest clue as to how biologically meaningful sequences of subunits might have originated in prebiotic polynucleotides or polypeptides.”

He put in his two cents on the problem of chirality as well, “Many researchers have attempted to find plausible natural conditions under which [left-handed] L-amino acids would preferentially accumulate over their [right-handed] D-counterparts, but all such attempts have failed. Until this crucial problem is solved, no one can say that we have found a naturalistic explanation for the origin of life. Instead, these isomer preferences point to biochemical creation.”

The reason I put those quotes there and will follow them with some papers by Dr. Kenyon is that since you referenced me to a site that mentions biochemical predestination, I figured you would want to read his latest work, as science is “self-critiquing,” he has critiqued the theory he helped found.

Also, an excerpt of a larger interview with Dean Kenyon:

Another problem that I find is in the quote:

  • “The immutable law of natural selection dictates that life will retain those features that foster survival.”

This apparent simple sentence makes reference to two theories that really are not science or Law being that they incorporate circular reasoning, that is, natural selection and the survival of the fittest.

From a rabid anti-creationist (posted a few years back at Space Battles):


“Evolution is promoted by its practitioners as more than mere science. Evolution is promulgated as an ideology, a secular religion — a full-fledged alternative to Christianity, with meaning and morality. I am an ardent evolutionist and an ex-Christian, but I must admit that in this one complaint — and Mr [sic] Gish is but one of many to make it — the literalists are absolutely right. Evolution is a religion. This was true of evolution in the beginning, and it is true of evolution still today…. Evolution therefore came into being as a kind of secular ideology, an explicit substitute for Christianity.”

Michael Ruse, professor of philosophy and zoology at the University of Guelph, Canada [recently moved to Florida], “How Evolution Became a Religion: Creationists Correct?” National Post, pp. B1, B3, B7 May 13, 2000.

What Can It Explain?

To summarize what I have already written, the modern position of the synthetic theory is: the struggle for existence plays no part in evolution. The direction of evolution is determined solely by the characteristics of those animals and plants that are successful breeders. We are unable to say anything about why a particular characteristic might favor, or prejudice, the survival of any particular animal or plant.

Natural Selection

Perhaps an even more damaging criticism of the concept of natural selection is that – limited though its content may be – it is so nebulous that it can be made to fit a whole range of mutually contradictory outcomes of the evolutionary process. Natural selection is entirely compatible with the notion that all organisms in stable environments have reached a fitness peak on which they will remain forever. At the same time natural selection is entirely compatible with the idea that all organisms should regress to the safest common denominator, a single-celled organism, and thus become optimally adapted to every habitat.

In precisely the same way, because of its infinitely elastic (explained more later) definition, natural selection can be made to explain opposed and even mutually contradictory individual adaptations. For example, Darwinists claim that camouflage coloring and mimicry (as in leaf insects) is adaptive and will be selected for, yet they also claim that warning coloration (the wasp’s stripes) is adaptive and will be selected for. Yet if both propositions are true, any kind of coloration will have some adaptive value, whether it is partly camouflaged or partly warning, and will be selected for. As a theory, then, natural selection makes no unique predictions but instead is used retrospectively to explain every outcome:And a theory that explains everything in this way, explains nothing. Natural selection is not a mechanism: it is a rationalization after the fact.

Natural selection is the process by which the most successful populate the world, and the less successful breeders die out – regardless of their respective characteristics.

  • “The giraffe has a long neck because…?”

Here we get stuck. The only help we get from synthetic evolution is that the giraffe has survived because it has survived. (This can be applied to the person who tried to explain to me how the cleaner fish “evolved” to pick the teeth of its predator, as well as the below posts.)

Is It Testable? Can It Predict?

Ernst Mayr made some startling admissions about Darwin’s model of mutation and natural selection. He said, “Popper is right; this model is so good that it can explain everything, as popper has rightly complained.” This relates to the requirement in science that a theory or model must make exclusionary predictions. If the concept is so generalized that it can explain any conceivable type of evidence, then it is of no value to science. For example, if a theory can explain both dark and light coloring in moths, both the presence and absence of transitional forms in the fossil record, complex life forms either above or below in rock strata, etc., then it has no value in making predictions. Now, Dr. Mayr (who was professor of zoology atHarvard University) believes that “ultimately, all variation is, of course, due to mutation….”

Professor Gould (Harvard’s esteemed paleontologist) has this to say when asked,“What role do mutations play in speciation?” Dr, Gould responded:

“A mutation doesn’t produce major new raw material. You don’t make a new species by mutating the species…. That’s a common idea people have; that evolution is due to random mutations. A mutation is NOT the cause of evolutionary change. Something else than natural selection brings about species at new levels, trends and directions.”

Keep in mind that Mayr and Gould are both evolutionists. In a discussion of how evolutionary theory can explain the fact that eels, which normally reproduce only in salt water, have certain landlocked species that reproduce in fresh water, Dr Weisskopt said,

“I think it was Medawar who said that one thing about the theory of evolution [and he quoted Popper] that it is not falsifiable, that whatever happens you can explain it. I think you have an example here.”

On the same subject, Dr. Fraser said,

“It would seem to me that there have been endless statements made and the only thing I have clearly agreed with through the whole day [referring to the Wistar Symposium] has been the statement made by Karl Popper, namely, that the real inadequacy of evolution, esthetically and scientifically, is that you can explain anything you want by changing your variable around.”

George Wald agreed,

“This cannot be done in evolution, taking it in its broad sense, and this is really all I meant when I called it tautologous in the first place. It can, indeed, explain anything. You may be ingenious or not in proposing a mechanism which looks plausible to human beings… but it is still unfalsifiable theory.”

Dr. Schutzenberger of the University of Paris reported on why all attempts to program a model of evolution on a computer had completely failed. He said that neo-Darwinism asserts that without anything further, selection brings about a statistically adapted drift when random changes are performed in a population. He insisted,

“We believe that is not conceivable. In fact if we try to stimulate such a situation by making changes randomly at the typographic level (by letters or blocks, the size of the unit does not matter) on computer programs we find that we have no chance (i.e., less than one in ten to the thousandth power) even to see what the modified program would compute: it just jams. Thus… we believe that there is a considerable gap in the neo-Darwinian theory of evolution, and we believe this gap to be of such a nature that it cannot be bridged within the current conception of biology.”

Near the end of the Symposium, Murray Eden explained:

“In consequence, the theory has been modified to the point that virtually every formulation of the principles of evolution is a tautology…. It is our contention that if ‘random’ is given a serious and crucial interpretation from a probabilistic point of view, the randomness postulate is highly implausible and that an adequate scientific theory of evolution must await the discovery and elucidation of new natural laws – physical, physicochemical, and biological…. In summary, it is our contention that the principle task of the evolutionist is to discover and examine mechanisms which constrain the variation of phenotypes to a very small class and to relegate the notion of randomness to a minor non-crucial role.”

Observable, Repeatable, and Refutable?

To the surprise of many casual observers, and to the embarrassment of many journalistic influences, evolution has never been demonstrated to be a viable explanation for life origins (or cosmic origins for that matter). By definition the scientific method requires that the objects or events under study must beOBSERVABLE, REPEATABLE, and REFUTABLE. Evolution certainly cannot be observed or repeated in the field or the laboratory. With this in mind, evolutionist Karl Popper, the honored referee of the modern scientific method, pointed out:

“It follows that any controversy over the question whether events which are in principle unrepeatable and unique ever do occur cannot be decided by science; it would be a metaphysical controversy.”

In his introduction to a 1971 publication of Darwin’s Origin of the Species, L. Harrison Matthews, British biologist and evolutionist, wrote:

“The fact of evolution is the backbone of biology, and biology is thus in the peculiar position of being a science founded on an unproved theory – is it then a science or a faith? Belief in the theory of evolution is thus exactly parallel to belief in special creation – both are concepts which believers know to be true but neither, up to the present, has been capable of proof.”

Intense controversy has erupted within the evolutionary camp. Newsweek featured an article by Sharon Begley titled “Science Contra Darwin.” She revealed:

“The great body of work derived from Charles Darwin’s revolutionary 1859 book, On the Origin of Species, is under increasing attack – and not just from creationists…. So heated is the debate that one Darwinian says there are times when he thinks about going into a field with more intellectual honesty: the used car business.”

Agnostic (non-creationist) Michael Denton (in his book Evolution: A Theory In Crisis) wrote that the evolutionary paradigm was, “… an idea which is more like a principle of medieval astrology than a serious twentieth century theory….” Steven M. Stanley (evolutionist), Proceedings of the National Academy of Science, 72:640-660, (1975), p.648.

“If most evolutionary changes occur during speciation events and if speciation events are largely random, natural selection, long viewed as a process guiding evolutionary change, cannot play a significant role in determining the overall course of evolution.” 

Richard C. Lewontin (evolutionist); “Adaptation.” Scientific American (and theScientific American Book, Evolution), Sept. 1978.

“Adaptation leads to natural selection, natural selection does not necessarily lead to greater adaptation … Natural Selection operates essentially to enable the organisms to maintain their state of adaptation rather than improve it … Natural selection over the long run does not seem to improve a species’ chances of survival, but simply enables it to ‘track,’ or keep up with, the constantly changing environment”

Pierre-Paul Grassé (evolutionist), Evolution of Living Organisms, Academic Press, New York (1977), pp. 97, 98.

“Mutations, in time, occur incoherently. They are not complementary to one another, nor are they cumulative in successive generations toward a given direction. They modify what pre-exists, but they do so in disorder.”

Arthur Koestler (evolutionist), Janus: A Summing Up, Random House, New York, 1978, pp. 184-185.

“In the meantime, the educated public continues to believe that Darwin has provided all the relevant answers by the magic formula of random mutation plus natural selection — quite unaware of the fact that random mutations turned out to be irrelevant and natural selection a tautology.”

  • ONE ASKS: “who survives?”
  • THE ANSWER: “the fittest.”
  • SO ONE ASKS: “who is the fittest?”
  • THE ANSWER: “those who survive.”

Philosophy professor Gregory Alan Pesely notes:

“One of the most frequent objections against the theory of natural selection is that it is a sophisticated tautology… What is most unsettling is that some evolutionary biologists have no qualms about proposing tautologies as explanations. One would immediately reject any lexicographer who tried to define a word by the same word, or a thinker who merely restated his proposition, or any other instance of gross redundancy; yet no one seems scandalized that men of science should be satisfied with a major principle which is no more than a tautology.”

Fitness does not always mean survival. The smartest, most resourceful persons are not necessarily those who leave the most offspring. So in recent years, evolutionists reduced the definition of “fitness” to simply “those who leave the most offspring.”But even this entails a rather circular argument. As geneticist Conrad Waddington of Edinburgh University noted:

“There, you do come to what is, in effect, a vacuous statement: ‘Natural selection is that some things leave more offspring than others;’ and you ask, ‘which leaves more offspring than others;’ and it is ‘those who leave more offspring;’ and there is nothing more to it than that…”

The Vitamin C Pseudogene Argument Crumbles… Slowly

See also: Pseudogenes Predicted To Fail by Creationists (Vestigial Response Added)

Bottom Line:

The failure to recognize the full implications of [non-protein–coding DNA] may well go down as one of the biggest mistakes in the history of molecular biology.

(cited in: Gibbs, W.W., The unseen genome: gems among the junk, Scientific American 289[5]:26–33, November 2003.)

…even the staunchest critics of creation theory recognize that “[i]t is impossible to prove absence of function for any region of DNA.”

Edward E. Max, “Plagiarized Errors and Molecular Genetics,” Sec. 5.4 . From: A Critique of “29 Evidences for Macroevolution”

Talk Origins in its 29+ Evidences for Macroevolution (written between 199 and 2004) quotes a 1999 study that purportedly proves their stance:

Furthermore, all of these genes have accumulated mutations at the exact rate predicted (the background rate of mutation for neutral DNA regions like pseudogenes) (Ohta and Nishikimi 1999).


Well, the tables have turned on neo-Darminian claims yet once again and science (not “scientism”) advances:

It is worth mentioning that this supposed truth for evolutionary theory is further along the wrong prediction mark than the proof of “Junk DNA” was along this path when I was debating in 97′ with people over at the Discover site.  (In fact, this “proof” is connected to the “junk DNA” position.) In 1997 people — in debate situation — said that evolution predicts junk DNA and that they have known of junk DNA for quite some time, thus proving evolutionary explanatory power. IN 2003, one of the first articles to hit the mainstream scientific press that this long held assumption was in jeopardy hit Discover and Scientific American magazines, two subscriptions I receive out of the many mags I get. Pictured is the first Discover magazine (yes, I have kept them) ruminations that this “proof” was disintegrating, like the vestigial organs “proof” did, cytochrome C differences, bacterial evolution, etc.

So debating a topic like this supposed proof is funny because it is much further along the scientific path than it was when I first debated the issue. Not to mention all the “evolutionary tree” models that are supposed to be factual when in fact their order is a topic of much debate. For instance, I posted a bit earlier a layman’s article on the argument within the evolutionary camp about mankind coming from orangutans rather than a chimpanzee split in the family tree… (this earlier post mentions the belief within the evolutionary camp that man came from some aquatic ancestor rather than orangutans). A few people likewise believe that apes (Gorillas) are descended from mankind in some way. For instance, Dr. Aaron G. Filler:

Dr. Aaron G. Filler, M.D., Ph.D. studied evolutionary theory under some of the leading biologists and anthropologists of our time: Ernst Mayr, Stephen J. Gould, David Pilbeam, and Irven DeVore. A neurosurgeon at the Institute for Spinal Disorders at Cedars Sinai Medical Center and past associate director of the Comprehensive Spine Center at UCLA, Dr. Filler has been a leading innovator in medical imaging and neuroscience. He is the author of Do You Really Need Back Surgery? (Oxford University Press), as well as numerous scientific articles and patents.

He wrote a book entitled The Upright Ape: A New Origin of the Species, in which he follows the footsteps of another well respected scientist showing that apes are most likely a breakaway group from mankind. The other scientist I mention is Dr. Geoffrey H. Bourne:

He was Director of Yerkes Regional Primate Research Center at Emory University, England. Dr. Bourne is Oxford educated, and is an American cell biologist/anatomist who was considered by most to be the worlds leading primatologist.

He said that apes are descended from man. Why would men of science believe such a thing? Because science has never seen any information being added to the evolutionary upward “slant” that is required by its theory (Darwinism, e.g., “scientism”). So since apes are less than us, Dr. Bourne says that science [not “scientism”] proves his theory due to observable facts. (SEE APPENDIX) All this though, junk DNA being disproved and a differing order of our family tree are other impediments to the Vitamin C Pseudogene argument. In order for this argument to work (and the subsequent predictions made to be coherent), he [the evolutionist] has to have all his ducks in order, this is something he does not have the luxury of (see image at top). One of the papers linked above (GULO pseudogenes have been intensively investigated) and its in-depth research led it two authors to say the following:

When examined in detail, the full pseudogene dataset we collected does not lend itself to a reasonable neo-Darwinian interpretation. Using standard bioinformatics tools and principles, we present alternative designs for at least the exon X portion of the GULO gene. These may be plausible due to nucleotide patterns being relevant as regulatory signals or the favouring of some codons for various possible reasons. We do accept that some mutations have occurred in this exon. But these novel proposals imply that the ancestors of the organisms studied may well never have had the exact same GULO sequence.

That last sentence really shows the assumptions made in this “proof” that steps away from true science and into the realm of historical science. And the historical sciences are fraught with bickering, changing branches of human lineage, and naturalistic philosophies that make the vitamin C pseudogene argument pretty vacuous.

The following is a good round-up of the problems seen in this line of argument, by Sean D. Pitman MD:

…in 2003, the same Japanese group published the complete sequence of the guinea pig GLO pseudogene, which is thought to have evolved independently, and compared it to that of humans [Inai et al, 2003]. 21 Surprisingly, they reported many shared mutations (deletions and substitutions) present in both humans and guinea pigs. Remember now that humans and guinea pigs are thought to have diverged at the time of the common ancestor with rodents. Therefore, a mutational difference between a guinea pig and a rat should not be shared by humans with better than random odds. But, this was not what was observed. Many mutational differences were shared by humans, including the one at position 97. According to Inai et al, this indicated some form of non-random bias that was independent of common descent or evolutionary ancestry. The probability of the same substitutions in both humans and guinea pigs occurring at the observed number of positions was calculated, by Inai et al, to be 1.84×10-12 – consistent with mutational hotspots.

What is interesting here is that the mutational hot spots found in guinea pigs and humans exactly match the mutations that set humans and primates apart from the rat (see figure below). 21,22 This particular feature has given rise to the obvious argument that Inai et al got it wrong. Reed Cartwright, a population geneticist, has noted a methodological flaw in the Inai paper:

“However, the sections quoted from Inai et al. (2003) suffer from a major methodological error; they failed to consider that substitutions could have occurred in the rat lineage after the splits from the other two. The researchers actually clustered substitutions that are specific to the rat lineage with separate substitutions shared by guinea pigs and humans. . .

If I performed the same analysis as Inai et al. (2003), I would conclude that there are ten positions where humans and guinea pigs experienced separate substitutions of the same nucleotide, otherwise known as shared, derived traits. These positions are 1, 22, 31, 58, 79, 81, 97, 100, 109, 157. However, most of these are shown to be substitutions in the rat lineage when we look at larger samples of species.

When we look at this larger data table, only one position of the ten, 81, stands out as a possible case of a shared derived trait, one position, 97, is inconclusive, and the other eight positions are more than likely shared ancestral sites. With this additional phylogenetic information, I have shown that the “hot spots” Inai et al. (2003) found are not well supported.” (see Link)

It does indeed seems like a number of the sequence differences noted by Cartwright are fairly unique to the rat – especially when one includes several other species in the comparison. However, I do have a question regarding this point.  It seems to me that there simply are too many loci where the rat is the only odd sequence out in Exon X (i.e., there are seven and arguably eight of these loci).  Given the published estimate on mutation rates (Drake) of about 2 x 10-10 per loci per generation, one should expect to see only 1 or 2 mutations in the 164 nucleotide exon in question (Exon X) over the course of the assumed time of some 30 Ma (million years).  Therefore, the argument of the mutational differences being due to mutations in the rat lineage pre-supposes a much greater mutation rate in the rat than in the guinea pig.  The same thing is true if one compares the rat with the mouse (i.e., the rat’s evident mutation rate is much higher than that of the mouse).

This is especially interesting since many of the DNA mutations are synonymous.  Why should essentially neutral mutations become fixed to a much greater extent in the rat gene pool as compared to the other gene pools? Wouldn’t this significant mutation rate difference, by itself, seem to suggest a mutationally “hot” region – at least in the rat?

Beyond this, several loci differences are not exclusive to the rat/mouse gene pools and therefore suggest mutational hotspots beyond the general overall “hotness” or propensity for mutations in this particular genetic sequence.

Some have noted that although the shared mutations may be the result of hotspots, there are many more mutational differences between humans and rats/guinea pigs as compared to apes.  Therefore, regardless of hotspots, humans and apes are clearly more closely related than are humans and rats/guinea pigs.

The problem with this argument is that the rate at which mutations occur is related to the average generation time.  Those creatures that have a shorter generation time have a correspondingly higher mutation rate over the same absolute period of time – like 100 years.  Therefore, it is only to be expected that those creatures with relatively long generation times, like humans and apes, would have fewer mutational differences relative to each other over the same period of time relative to those creatures with much shorter generation times, like rats and guinea pigs.

What is interesting about many of these mutational losses is that they often share the same mutational changes.  It is at least reasonably plausible then that the GULO mutation could also be the result of a similar genetic instability that is shared by similar creatures (such as humans and the great apes).

This same sort of thing is seen to a fairly significant degree in the GULO region.  Many of the same regional mutations are shared between humans and guinea pigs.  Consider the following illustration yet again:

Why would both humans and guinea pigs share major deletions of exons I, V and VI as well as four stop codons if these mutations were truly random?  In addition to this, a mutant group of Danish pigs have also been found to show a loss of GULO functionality.  And, guess what, the key mutation in these pigs was a loss of a sizable portion of exon VIII.  This loss also matches the loss of primate exon VIII.  In addition, there is a frame shift in intron 8 which results in a loss of correct coding for exons 9-12.  This also reflects a very similar loss in this region in primates (see Link).  That’s quite a few key similarities that were clearly not the result of common ancestry for the GULO region.  This seems to be very good evidence that many if not all of the mutations of the GULO region are indeed the result of similar genetic instabilities and that are prone to similar mutations – especially in similar animals.

As an aside, many other genetic mutations that result in functional losses are known to commonly affect the same genetic loci in the same or similar manner outside of common descent.  For example, achondroplasia is a spontaneous mutation in humans in about 85% of the cases. In humans achondroplasia is due to mutations in the FGFR2 gene. A remarkable observation on the FGFR2 gene is that the major part of the mutations are introduced at the same two spots (755 C->G and 755-757 CGC->TCT) independent of common descent. The short legs of the Dachshund are also due to the same mutation(s). The same allelic mutation has occurred in sheep as well.

(SOURCE)

All this is to say, yet again, that this “evidence” is anything but!

Wiki Section:

By definition, pseudogenes lack a function. However, the classification of pseudogenes generally relies on computational analysis of genomic sequences using complex algorithms.[17] This has led to the incorrect identification of pseudogenes. For example the functional, chimeric gene jingwei in Drosophila was once thought to be a processed pseudogene. [18]

It has been established that quite a few pseudogenes can go through the process of transcription, either if their own promoter is still intact or in some cases using the promoter of a nearby gene; this expression of pseudogenes also appears to be tissue-specific.[4] In 2003, Hirotsune et al. identified a retrotransposed pseudogene whose transcript purportedly plays a trans-regulatory role in the expression of its homologous gene, Makorin1 (MKRN1) (see also RING finger domainubiquitin ligases), and suggested this as a general model under which pseudogenes may play an important biological role.[19] Other researchers have since hypothesized similar roles for other pseudogenes.[20] A bioinformatics analysis has shown that processed pseudogenes can be inserted into introns of annotated genes and be incorporated into alternatively spliced transcripts. [10] Hirotsune’s report prompted two molecular biologists to carefully review scientific literature on the subject of pseudogenes. To the surprise of many, they found a number of examples in which pseudogenes play a role in gene regulation and expression,[21] forcing Hirotsune’s group to rescind their claim that they were the first to identify pseudogene function.[22] Furthermore, the original findings of Hirotsune et al. concerning Makorin1 have recently been strongly contested;[23] thus, the possibility that some pseudogenes could have important biological functions was disputed. Additionally, University of Chicago and University of Cincinnati scientists reported in 2002 that a processed pseudogene called phosphoglycerate mutase 3 (PGAM3P) actually produces a functional protein.[24] and Two 2008 publications in Nature discusses that some endogenous siRNAs are derived from pseudogenes, and thus some pseudogenes play a role in regulating protein-coding transcripts.[25][26]

AIG & PDF Sources [PDF source near top]:

….Many of those mammals found unable to synthesize ascorbic acid have regions of their genome that are believed to correspond to parts of the functional GULO gene that is found in those mammals found capable to synthesizing GULO, and thus vitamin C. Evolutionists have cited these apparently vestigial remnants of GULO to make dysteleological arguments against an Intelligent Designer. In addition, they have argued that lesions found in common between the orthologous GULO pseudogenes of simian primates (‘shared mistakes’) argue strongly for their origins from a common ancestor, and all but rule out an independent inactivation of the GULO gene among different simian primates (including humans).

Previous studies of the orthologous primate GULO gene and pseudogene have focused on those parts of a few exons that appear to correspond between humans and rats. A more recent study1 is much more comprehensive. It is now believed that, relative to the 12 exons that comprise the functional rat GULO gene, the human GULO pseudogene is limited to counterparts of exons 4, 7, 9, 10, and 12. Owing to the fact that the guinea pig and the simian primates are obviously not sister groups [see figure near top], it is impossible for the guinea pig GULO pseudogene and the human GULO pseudogene to have both originated from the same ancestral pseudogene. Furthermore, not only are the inactivations of GULO in the guinea pig and primates clearly independent events based on phylogenetic analysis [see figure near top], but also on inferred evolutionistically believed times of inactivation….

Inai, Y., Ohta, Y. and Nishikimi, M., The whole structure of the human non-functional L-gulono-γ-lactone oxidase gene—the gene responsible for scurvy—and the evolution of repetitive sequences thereon, J. Nutritional Science and Vitaminology (Tokyo)49(5):315–319, 2003.

UPDATE:

The “pseudogene” argument (of which Vitamin C Pseudogene is part of) is being shown to not be a “vestige” as claimed and “predicted” by Darwinian theory. Much like the Haeckel’s list of over 100 vestigial organs, science shows that predictions made like this fail. If the predictions of design were assumed, more lives would have been saved and true science would have flourished. JBS Haldane however, said (predicted) that “natural selection cannot possibly select for millions of new mutations over the course of human evolution, Kimura developed the idea of “Neutral Evolution.” If “Haldane’s Dilemma”  was correct, the majority of DNA must be non-functional. Hence, the pseudogene argument. This is an argument that has failed due to recent science, no predictive power left in it. Which is no small issue, since, it is this “predictive value” that makes this argument valid.

Faulkner (in 2009) worked with mice and humans and showed clearly that this RNA/Retrotranposons relationship were not random, and thus transcription is shown to be influenced wholly or partly by this “junk DNA.” — “Therefore, more than one third of the mouse and human genomes, previously thought to be non-functional, may play some role in the regulation of gene expression” (scientists from Jackson Maine, USA laboratories). Creationists have long figured this “junk DNA” to be functional… making design predictions more accurate.

Thankfully, not everyone bought this idea. In the late 1980s, New Zealand–born Australian immunologist Malcolm Simons recognized patterns, or order, in the non-coding DNA that indicated to him that the code must have a function, but others ridiculed the idea. In the mid-1990s, he patented the non-coding DNA (95%) of all organisms on Earth. The company he founded, Genetic Technologies, now reaps license fees from all technologies being developed to cure disease that involve the non-coding DNA. It’s quite controversial, of course, paying such license fees. And since factors involved in all sorts of diseases, such as breast cancer, Crohn’s disease, Alzheimer’s, heart disease, ovarian and skin cancer, are being found in the ‘junk’, Genetic Technologies is doing quite well.

The “vitamin C gene” in question here (L-gulano-g-lactone oxidase gene) is only a valid argument if:

a) a non-functional version of the gene was shown to be functional at some point in our human lineage, it says nothing about ancestors (kinds, or species) who could have been created with an active gene.

b) If the lineage of man can truly be traced through evolutionary ancestors, which it cannot.

c) The same gene could have been inactivated by the same mutation occurring independently is said to be too improbable by strict neo-Darwinists. (Ironic) However, if there is, or was, a mechanism of mutation that favors certain locations in the gene (a hot spot), the odds against an independent occurrence of the mutation drop according to the strength of that bias. This, by-the-way, is more probable considering the fall of the pseudogene argument. In other words, this prediction would now be of a higher order and is an example of loss of function and a disordering of optimum ability. Something the creation model predicts, it is the opposite of what Darwinism requires.

d) Likewise, in order for this line of reasoning to work, a human genome must be compared to an organism with a functioning gene for synthesizing vitamin C. Of course we know they found it in rats (Nishikimi, 1994). Four of the 12 exons (Science Dictionary: A segment of a gene that contains information used in coding for protein synthesis; exons are the modular coding regions of the gene). Here is the downfall, two-thirds of the homologous rat gene is completely missing. Which is to say: “This DNA sequence, labeled as a pseudogene, might have an entirely different function than the rat gene.” This would be — with recent peer reviewed articles in Discover, Scientific American, Nature, Science Weekly, and other pubvlications — be of a higher order than merely saying it is a pseudogene. In other words, the previous predictions are mute and shows that the argument is from silence, or non-science.

Stating that only the last enzyme is missing for the pathway to convert glucose to vitamin C might imply to the untrained individual that there is a biochemical pathway that leads to a dead end. Actually, the biochemical pathway that leads to the synthesis of vitamin C in rats also leads to the formation of five-carbon sugars in the pentose phosphate pathway present in virtually all animals (Linster and Van Schaftingen 2007). There are several metabolic intermediates in this pathway illustrating that these substances can be used as precursors for many compounds in the cell. In the pentose phosphate pathway, five-carbon sugars are made from glucose (a six-carbon sugar) to be used in the synthesis of DNA, RNA, and many energy producing substances such as ATP and NADPH (Garrett 1999). Animals that synthesize vitamin C can use both pathways illustrated in the simplified diagram below. Humans and the other animals “less fortunate” than rats only use the pentose phosphate pathway.

There is no dead end or wasted metabolic intermediates, and there is no need to have the enzyme to make vitamin C since humans are able to get all of the vitamin C they need from food substances. Thousands of human pseudogenes have been catalogued, but in spite of the similarities to functional genes, the exact role of pseudogene sequences in the genome are not known by any scientist. It is not necessary to assume that pseudogenes are remnants of once functioning genes that have been lost and now clutter the genome like junk in a rubbish heap.

Criswell, D. 2007. Adam and Eve, Vitamin C, and Pseudogenes. Acts & Facts. 36 (5).

Conclusion Then

As was said before the known factors of the pentose phosphate pathways:

  • The failure to recognize the full implications of [non-protein–coding DNA] may well go down as one of the biggest mistakes in the history of molecular biology. (cited in: Gibbs, W.W., The unseen genome: gems among the junk, Scientific American 289[5]:26–33, November 2003.)
  • …even the staunchest critics of creation theory recognize that “[i]t is impossible to prove absence of function for any region of DNA.” (Edward E. Max, “Plagiarized Errors and Molecular Genetics,” Sec. 5.4 . From: A Critique of “29 Evidences for Macroevolution”)

So, to sum up, at best this could be viewed as a theological argument: “what should have God done if he did create ‘A’.” At worst it is an argument that has not evolved with science correcting itself and is stuck in the 90’s science and not the mid-to-late part of the first decade of the beginning of the 21st century — science. Science has evolved, have the evolutionists?

This is an excerpt from the much hated book, Of Pandas and People, pp 34-40 (click to enlarge):

Here is the continuation of the devolving of primates:


APPENDIX


1. It takes 6 million years for one mutation to arise in a DNA binding site.

2. 6 million years is how long, historically, one has to get from primates to humans.

3. Humans differ from primates in hundreds of ways, requiring probably thousands of different gene mutations.

4. What’s more, many of the differences between primates and humans would require coordinated mutations. For example, the correct legs, feet, pelvis, spine, and neck to walk upright are differences which individually are useless by themselves.

5. Experiments with bacteria (i.e. with population sizes and mutation rates much higher than primates and humans) suggest that a single protein cannot mutate six or more times in a coordinated fashion in a timespan less than the known age of the universe.

6. Given these numbers, it is impossible for humans to have evolved from primates.